Estrone is a major circulating estrogen. While it has relatively weak estrogenic activity on its own, it can be converted to stronger estrogens within tissues. The amount of estrone increases with aging and obesity, and is one of the most inflammatory estrogens. Typically recognized as the “female hormone,” in excess this class of compounds can impair liver function, increase stress hormones, promote fungal overgrowth, and digestive symptoms. Other signs of excess estrogen are aggression and water retention.
Stress can be anything that interrupts the body’s homeostasis. This could be physical, emotional, psychological, infectious, among countless other contributors to systemic stress. Stress manifests through several different hormones, signaling molecules, and other processes that have numerous consequences on health. Stress tends to suppress the immune system, deplete nutrients, disrupt organ function, break down tissue, impair metabolism and ultimately contribute to intlammation and oxidative stress. All of these can result in symptoms, from fatigue and brain fog, to digestive issues, impairments in metabolism, and more. Periodic stress is normal and even healthful, but chronic stress plays a pivotal role in nearly every health issue.
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