Serotonin is released in high amounts from the gastrointestinal tract during irritation, where it becomes involved in the immune response. Serotonin can activate pro-clotting and pro-inflammatory processes throughout the body. Its levels are increased in certain inflammatory conditions. Serotonin can also inhibit metabolism systemically, contributing to weight gain and lethargy. Serotonin can promote the HPA axis, which produces stress factors like cortisol, among other stress systems.
Inflammation is a part of the immune system that is geared towards the breakdown of cells, foreign matter and microorganisms. While inflammation is imperative for resisting infections and overcoming tissue damage, it should be resolved quickly thereafter. Inflammation can drive the stress systems, contribute to oxidative stress and impair metabolism, and thus plays a key role in various health issues if chronically activated.
Stress can be anything that interrupts the body’s homeostasis. This could be physical, emotional, psychological, infectious, among countless other contributors to systemic stress. Stress manifests through several different hormones, signaling molecules, and other processes that have numerous consequences on health. Stress tends to suppress the immune system, deplete nutrients, disrupt organ function, break down tissue, impair metabolism and ultimately contribute to intlammation and oxidative stress. All of these can result in symptoms, from fatigue and brain fog, to digestive issues, impairments in metabolism, and more. Periodic stress is normal and even healthful, but chronic stress plays a pivotal role in nearly every health issue.
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