The Organic Acids test measures the amount of various intermediates in metabolism in the urine. This approach is typically used clinically to diagnose inborn (genetic) errors of metabolism, issues with various metabolic pathways due to the inherited malfunctioning of certain enzymes. However, it can be broadly used to characterized a number of bottlenecks in metabolism, caused by genes or the environment, that can result in any number of symptoms including fatigue and brain fog, poor gut health and a low metabolism.
The types of these organic acids include:
✧ Byproducts / intermediates of branched chain amino acid metabolism: these are the most abundant and common. Elevated levels suggest you have a problem in breaking down these amino acids for energy.
✧ Byproducts / intermediates of tyrosine or phenylalanine metabolism: also very abundant and common. Elevated levels suggest you have a problem in breaking down these amino acids for energy.
✧ Byproducts / intermediates of fatty acid metabolism: High levels mean you have an issue breaking down fat for energy.
✧ Intermediates of energy metabolism: especially important. This is where the breakdown of all food converges. If you have high levels of any of these, then you have a “backup” in your energy production.
✧ Bacterial / fungal metabolites: you might have an infection or overgrowth if you see these.
✧ Byproducts of sulfur metabolism: you could have an issue with sulfur metabolism.
Includes:
2-DECENEDIOIC ACID
2-ETHYL-3OH-PROPIONIC
2-METHYLACETOACETIC ACID
2-METHYLBUTYRYLGLYCINE
2-METHYLGLUTACONIC ACID
2-OCTENEDIOIC ACID
2-OCTENOIC ACID
2-OXO-3-METHYVALERIC ACID
2-OXO-ADIPIC ACID
2-OXO-BUTYRIC ACID
2-OXO-GLUTARIC ACID
2-OXO-ISOCAPROIC ACID
2-OXO-ISOVALERIC ACID
2OH-3-METHYLVALERIC ACID
2OH-ADIPIC ACID
2OH-BUTYRIC ACID
2OH-GLUTARIC ACID
2OH-ISOCAPROIC ACID
2OH-ISOVALERIC ACID
2OH-PHENYLACETIC ACID
3-METHYLCROTONYLGLYCINE
3-METHYLGLUTACONIC ACID
3-METHYLGLUTARIC ACID
3OH-2-METHYLBUTYRIC ACID
3OH-2-METHYLVALERIC ACID
3OH-3-METHYLGLUTARIC ACID
3OH-ADIPIC ACID
3OH-BUTYRIC ACID
3OH-DODECANEDIOIC ACID
3OH-DODECANOIC ACID
3OH-GLUTARIC ACID
3OH-ISOBUTYRIC ACID
3OH-ISOVALERIC ACID
3OH-PROPIONIC ACID
3OH-SEBACIC ACID
3OH-VALERIC ACID
4OH-BUTYRIC ACID
4OH-CYCLOHEXYLACETIC ACID
4OH-PHENYLACETIC ACID
4OH-PHENYLLACTIC ACID
4OH-PHENYLPYRUVIC ACID
4OH-PHEYLPROPIONIC ACID
5-HIAA
5-OXO-PROLINE
5OH-HEXANOIC ACID
ACETOACETIC ACID
ACONITIC ACID
ADIPIC ACID
BUTYRYLGLYCINE
CITRIC ACID
Creatinine, Random Urine
CROTONYLGLYCINE
DECADIENEOIC ACID
DODECANEDIOIC ACID
ETHYLMALONIC ACID
FUMARIC ACID
GLUTACONIC ACID
GLUTARIC ACID
GLYCERIC ACID
HEXANOYLGLYCINE
HOMOGENTISIC ACID
HOMOVANILLIC ACID
INTERPRETATION
ISOBUTYRYLGLYCINE
ISOCITRIC ACID
ISOVALERYLGLYCINE
LACTIC ACID
MALIC ACID
MALONIC ACID
METHYLCITRIC ACID
METHYLMALONIC ACID
METHYLSUCCINIC ACID
MEVALONOLACTONE
N-ACETYLASPARTIC ACID
N-ACETYLTYROSINE
N-VALERYLGLYCINE
OCTANOIC ACID
OROTIC ACID
PHENYLACETIC ACID
PHENYLLACTIC ACID
PHENYLPROPIONYLGLYCINE
PHENYLPYRUVIC ACID
PROPIONYLGLYCINE
PYRUVIC ACID
SEBACIC ACID
SUBERIC ACID
SUBERYLGLYCINE
SUCCINIC ACID
SUCCINYLACETONE
THYMINE
TIGLYLGLYCINE
TRANS-CINNAMYLGLYCINE
URACIL
VMA
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